Hemophilia Bis a rare genetic blood disorder that affects approximately 4,000 males in the U.S. and 26,000 malesworldwide. Spark's hemophilia B program has the potential to build on our leading hemophilia portfolio and could offer patients with this bleeding disorder a potential new treatment option.". It has a pipeline of product candidates targeting multiple rare blinding conditions, hematologic disorders and neurodegenerative diseases. Oversee the development of medical strategies for Spark products that can be used to guide developme. The company's expertise across research, clinical, regulatory and manufacturing builds on a legacy of innovation and excellence in gene therapy established by Spark's team while at The Children's Hospital of Philadelphia Center for Cellular and Molecular Therapeutics. Iowa City, Iowa, United States. View contacts for Spark Therapeutics to access new leads and connect with decision-makers. Sparks robust pipeline includes SPK-RPE65, a fully enrolled, pivotal Phase 3 program in blindness due to mutations in the RPE65 gene, SPK-CHM for the treatment of choroideremia, and SPK-FIX, a program for the potential treatment of hemophilia B through a global collaboration with Pfizer Inc., as well as preclinical programs to address neurodegenerative diseases and other retinal degenerative diseases and hematologic disorders. To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/spark-therapeutics-announces-gene-therapy-collaboration-in-hemophilia-b-with-pfizer-inc-300005849.html, Cision Distribution 888-776-0942 Find company research, competitor information, contact details & financial data for Spark Therapeutics, Inc. of Philadelphia, PA. Get the latest business insights from Dun & Bradstreet. Spark's current valuation leaves room for substantial upside in the following years. This study builds on the Spark team's previous groundbreaking work in advancing the first two gene therapy clinical studies in hemophilia B, the second of which achieved the highest levels of factor IX expression of any gene therapy trial to date. Spark's integrated gene therapy platform builds on two decades of research, development and manufacturing at The Children's Hospital of Philadelphia, including human trials conducted across diverse therapeutic areas and routes of administration. Their latest funding was raised on May 27, 2014 from a Series B round. They acquired Genable Technologies Ltd. for $15.2M. Spark Therapeutics, Inc. is a gene therapy company. Its pipeline includes a product candidate targeting choroideremia (CHM), which is in a Phase I/II clinical . The company's product candidates are in the field of retina-directed gene therapies, liver-directed gene therapies, and central nervous . Acting Vice-Chair for Education, Department of Neurology. Spark Therapeutics, Inc. Apr 2017 - Present 5 years 8 months. Our robust pipeline includes a Phase 3 program in blindness due to mutations in the RPE65 gene and a Phase 1/2 program in hemophilia B, as well as preclinical programs to address neurodegenerative diseases and other retinal degenerative diseases and hematologic disorders. . programs and capabilities needed to deliver its pioneering gene therapy products. from 8 AM - 9 PM ET. Lexington, Massachusetts. PHILADELPHIA, PA, USA I February 01, 2021 I Spark Therapeutics, a member of the Roche Group (SIX: RO, ROG; OTCQX: RHHBY) and a fully integrated, commercial gene therapy company dedicated to challenging the inevitability of genetic . About. Funding Rounds Number of Funding Rounds 2 Total Funding Amount $122.8M Spark Therapeutics has raised a total of $122.8M in funding over 2 rounds. 81% of employees would recommend working at Spark Therapeutics to a friend and 70% have a positive outlook for the business. It is a subsidiary of Hoffmann-La Roche. About Spark Therapeutics Spark Therapeutics is developing potentially curative, one-time gene therapy products to transform the lives of patients and re-imagine the treatment of debilitating diseases. R&D in Biotech, Environmental and various industries (no marketing product yet) Tags Biotechnology, Healthcare Venture Deals, Healthcare IPO Companies managed Acquired/Merged Spark Therapeutics Headquarters 3737 Market Street Suite 1300 Philadelphia, PA 19104 US (888) 772-7560 info@sparktx.com Web Site N/A Milestones Related Companies Head of Corporate Security. There is currently no pharmacologic treatment for this form of inherited retinal degeneration, which ultimately causes irreversible blindness. Which funding types raised the most money? philadelphia, oct. 22, 2013 /prnewswire/ -- spark therapeutics, a new, fully integrated company developing gene-based medicines for a wide range of debilitating diseases, announced today it has. Fully Integrated Gene Therapy Company with Deep Clinical Pipeline Spun out of The Children's Hospital of Philadelphia. Spark Therapeutics, Inc. focuses on the development of gene therapy products for patients suffering from debilitating genetic diseases. Spark builds on the work of CHOP's Center for Cellular and Molecular Therapeutics (CCMT), established in 2004 as a world-class center for gene therapy translational research and manufacturing. "Their vision and long-term dedication have enabled us to effectively address many of the key challenges facing the field and to emerge with one of the industry's most robust clinical-stage gene therapy pipelines; as well as exclusive rights to commercialize a proprietary manufacturing platform, supply from a world-class manufacturing facility and a founding team with a proven track record of executing safe and effective gene therapy trials for nearly two decades. PHILADELPHIA, Oct. 22, 2013 /PRNewswire/ --Spark Therapeutics, a new, fully integrated company developing gene-based medicines for a wide range of debilitating diseases, announced today it has launched with a $50 million capital commitment from The Children's Hospital of Philadelphia (CHOP) to advance and commercialize multiple ongoing programs with clinical proof of concept. Spark Therapeutics is developing potentially curative, one-time gene therapy products to transform the lives of patients and re-imagine the treatment of debilitating diseases. About Spark TherapeuticsSpark Therapeutics is developing potentially curative, one-time gene therapy products to transform the lives of patients and re-imagine the treatment of debilitating diseases. The team at Spark has incredible goals for the treatment of diseases including hemophilia B and inherited blindness, and we look forward to working with them to deliver groundbreaking new treatments to patients in need.". Director, Neurology Residency Program. Spark Therapeutics, Inc. All news about SPARK THERAPEUTICS INC. CombiGene's and Neurochase's preclinical study provides valuable information for the up.. GMP production of CG01 made available for preclinical studies planned to enable First i.. Dr. High, who pioneered the development of AAV-mediated gene therapy for hemophilia, noted, "Pfizer's longtime experience in hemophilia, including strong relationships with physicians, patients and payors, as well as clinical, regulatory and commercial capabilities, will complement our team's deep knowledge of AAV-mediated gene transfer for the disease. Read more Corporate responsibility Posted 2w ago . $64.7 M FY, 2018 Market Capitalization $4.4 B 2019-12-17 Company summary Overview Spark Therapeutics is a gene therapy company. Spark Therapeutics was founded in 2013 and became a Member of the Roche Group in 2019. Spark Therapeutics is actively using 64 technologies for its website, according to BuiltWith. In hemophilia B, the company's Phase 1/2 study is enrolling up to 15 subjects who will receive a one-time dose through an intravenous infusion of the gene responsible for expressing factor IX. Spark Therapeutics has acquired Genable Technologies Ltd. on Mar 7, 2016. Which investors participated in the most funding rounds? Its products include LUXTURNA (voretigene neparvovec) for the treatment of patients with confirmed biallelic RPE65 mutation-associated retinal dystrophy and viable retinal cells. Spark is a gene therapy leader seeking to transform the lives of patients suffering from debilitating genetic diseases by developing one-time, life-altering treatments. Under the terms of the agreement, Spark will receive an upfront payment of $20 million and will be eligible for additional development and commercialization milestone payments of up to $260 million for multiple hemophilia B product candidates that may be developed under the collaboration. SaaS, Android, Cloud Computing, Medical Device). Spark Therapeutics revenue is $93.5M annually. The Spark team was among the first to demonstrate human clinical proof of concept in two distinct organ systemsthe eye and the liverestablishing a strong foundation for the company's current programs, and has clinical experience in 15 studies across diverse genetic and non-genetic diseases and five distinct routes of administration. Detailed information on company financials and operating reports can be found here: . The average Spark Therapeutics salary ranges from approximately $93,180 per year for a Research Associate to $158,235 per year for a Senior Scientist.The average Spark Therapeutics hourly pay ranges from approximately $44 per hour for a Research Associate to $66 per hour for a Project Manager.Spark Therapeutics employees rate the overall compensation and benefits package 4.6/5 stars. The founding team includes scientists who have led the advancement of gene therapy over the past two decades, establishing human proof of concept of the expression of . When typing in this field, a list of search results will appear and be automatically updated as you type. There are 69 replacement spark plugs for Champion CJ7Y. The Company focuses on treating orphan diseases. Notably, Spark has exclusive rights to commercialize CHOP's proprietary manufacturing technology and will use clinical-grade gene therapy vectors produced by the CCMT's state of the art good manufacturing practices (cGMP) clinical facility. Spark Therapeutics, Inc. is a developer of gene therapy treatments, which treat debilitating genetic diseases. Spark's proprietary, bioengineered vectors are designed to deliver a high-activity Factor IX gene to patients, enabling endogenous production of Factor IX, with the potential to be effective for a number of years. About Spark Therapeutics. Trademark applications show the products and services that Spark Therapeutics is developing and marketing. AAPL, FB, TWTR), Total amount raised across all funding rounds, Total number of Crunchbase contacts associated with this organization, Total number of employee profiles an organization has on Crunchbase, Total number of investment firms and individual investors, Descriptive keyword for an Organization (e.g. Contents 1 History 2 Products and pipeline 2.1 Voretigene neparvovec 2.2 Fidanacogene elaparvovec 2.3 SPK-8011 2.4 SPK-7001 2.5 SPK-3006 We have built a fully integrated company, combining our proprietary adeno-associated viral (AAV) gene therapy platform with excellence in R&D, manufacturing and . [1] It is a subsidiary of Hoffmann-La Roche . Seed, Series A, Private Equity), Whether an Organization is for profit or non-profit, General contact email for the organization, Auto-generated name of transaction (e.g. Navigate a database of ~2k spark plugs and cross - reference products for them. High, M.D, a gene therapy pioneer who has served as the director of the CCMT since its inception. Limited products and pipeline Career advancement opportunities limited. Spark Therapeutics peak revenue was $93.5M in 2021. Audentes Therapeutics (BOLD) is a clinical stage biotechnology company focused on developing and commercializing gene therapy products for rare diseases that are caused by single gene defects.. October was an important month for Spark Therapeutics . The founding team includes scientists who have led the advancement of gene therapy over the past two decades, establishing human proof of concept of the expression of gene. Leading gene therapy Company will partner with established market leader to develop a potential new treatment paradigm for hemophilia B. PHILADELPHIA, Dec. 8, 2014 /PRNewswire/ -- Spark Therapeutics, a late-stage gene therapy company developing treatments for debilitating genetic diseases, announced today that it has entered into a global collaboration with Pfizer Inc. for the development and potential commercialization of SPK-FIX, a development program advancing proprietary, bio-engineered adeno-associated virus (AAV) vectors for the potential treatment of hemophilia B. What is Spark Therapeutics's Revenue? Spark Therapeutics is developing potentially curative, one-time gene therapy products to transform the lives of patients and re-imagine the treatment of debilitating diseases. Developed and implemented strategic repositioning, restructuring, and full operational management . SPK-CHM and SPK-FIX are potential blockbuster products. Mutations in the RPE65 gene lead to reduced or absent levels of RPE65 isomerohydrolase activity, blocking the visual cycle and resulting in progressive vision loss and ultimately, blindness [1]. Current treatment requires recurrent intravenous infusions of either plasma-derived or recombinant Factor IX to control bleeding episodes. Spark plans to leverageSPK-RPE65to address a broad spectrum of blinding conditions, and also has established a pipeline of gene therapy candidates to treat hematologic and neurodegenerative disorders. Our mission at Spark Therapeutics is to challenge the inevitability of genetic disease by discovering, developing and delivering potential treatments in ways unimaginableuntil now. AAV has been demonstrated in clinical studies to be a safe and effective vehicle for the delivery of genetic material into targeted cells and provides unique advantages over alternative delivery approaches. These include Viewport Meta, IPhone / Mobile Compatible, and SPF. 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